Mike Weinstock, MD and Mizuho Spangler, DO

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Mike and Mizuho review a case of a woman with facial swelling. We discuss the differential diagnosis of a patient who presents with facial swelling and the final diagnosis of superior vena cava syndrome.


  1. SVC syndrome occurs 15,000 times per year in the US.

  2. 60% of SVC syndromes are malignant in origin and 35% are catheter-associated from permanent indwelling lines for chemo or antibiotic administration.

  3. 82% of SVC syndromes present with facial edema and/or erythema.